1. The constant rejection from job applications left her feeling a deep sense of downheartedness.
2. He tried to hide his downheartedness after his team lost the championship game.
3. The news of her failing health filled her with a sense of downheartedness.
4. Despite her best efforts, she couldn't shake off the feeling of downheartedness after her breakup.
5. His failure to secure a promotion at work led to a sense of downheartedness that lingered for weeks.
6. The constant criticism from his boss left him with a feeling of downheartedness.
7. The loss of her beloved pet left her in a state of downheartedness that was hard to overcome.
8. The financial struggles she faced caused a deep sense of downheartedness and despair.
9. The sudden death of a close friend filled him with a sense of downheartedness that was hard to shake.
10. The constant setbacks in her career left her with a feeling of downheartedness that seemed never-ending.